Monday, 11 March, 2013
SPEAKER: Jonathan Forde, Hobert and William Smith Colleges
TITLE: Modeling the Immune Reaction to Hepatitis Delta infection
ABSTRACT: Hepatitis Delta Virus (HDV) is a dependent satellite virus of the more common Hepatitis B Virus. HDV encodes only one protein of its own, relying on HBV to supply the additional proteins needed for its replication cycle. Although HDV is noncytotoxic and present few targets for immune reaction, the symptoms of patients with HBV-HDV co-infection are much worse than those infected with HBV alone. The cause of this negative outcome is not clear. This talk presents o.d.e. models for the interaction of HBV, HDV and the antigen-speciﬁc immune responses to explore recovery from T cell exhaustion as a possible explanation of negative outcomes in chronic HBV/HDV co-infection. Additionally, the role of the immune reaction in several other HDV-related phenomena will be discussed, including drug treatment failure and fluctuations in viral load.
Pizza will be available at 3:10 p.m.