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Computational/Applied Math Seminar

Wednesday, 26 March, 2014

SPEAKER:  Prof. Vasilios Alexiades, UTK

TITLE: Parameter Identification via sensitivity and optimization

ABSTRACT: We study a model of a biochemical cascade (triggered by photons in retinal photoreceptors, which constitutes the first stage of vision). The cascade (with multi-stage shutoff of activated rhodopsin) is described by 70 reactions involving 16 primary parameters. A sensitivity analysis suggests that 4 of the parameters affect the response the most. We present an optimization approach to find parameters that result in desired peak and timing of response matching experimental data.


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